Sex differences in ochratoxin A nephrotoxicityA molecular approach to the mechanism of action

  1. Pastor Castro, Laura
Dirigida por:
  1. Adela López de Cerain Salsamendi Director/a
  2. Ariane Vettorazzi Armental Codirector/a

Universidad de defensa: Universidad de Navarra

Fecha de defensa: 05 de julio de 2017

Tribunal:
  1. María Pilar Lostao Crespo Presidente/a
  2. Paul Cordero Secretario/a
  3. Francisco Javier Campión Zabalza Vocal
  4. Fermín Ignacio Milagro Yoldi Vocal
  5. Eduardo de la Peña Torres Vocal

Tipo: Tesis

Teseo: 122795 DIALNET lock_openDadun editor

Resumen

This work is included in the line of research carried out in Toxicology which studies the mycotoxin ochratoxin A (OTA) from the point of view of its mechanism of action. OTA causes various toxic effects, such as nephrotoxicity, hepatotoxicity, immunosuppression, neurotoxicity and teratogenicity. However, the main issue concerning OTA effect is its carcinogenic potential in kidney, the target organ. The aim of this research project was to explore the impact of sex on OTA-induced gene expression response in order to determine the key events that might be involved in the early events of the carcinogenic process.