Sex differences in ochratoxin A nephrotoxicityA molecular approach to the mechanism of action

  1. Pastor Castro, Laura
unter der Leitung von:
  1. Adela López de Cerain Salsamendi Doktorvater/Doktormutter
  2. Ariane Vettorazzi Armental Co-Doktorvater/Doktormutter

Universität der Verteidigung: Universidad de Navarra

Fecha de defensa: 05 von Juli von 2017

Gericht:
  1. María Pilar Lostao Crespo Präsident/in
  2. Paul Cordero Sekretär/in
  3. Francisco Javier Campión Zabalza Vocal
  4. Fermín Ignacio Milagro Yoldi Vocal
  5. Eduardo de la Peña Torres Vocal

Art: Dissertation

Teseo: 122795 DIALNET lock_openDadun editor

Zusammenfassung

This work is included in the line of research carried out in Toxicology which studies the mycotoxin ochratoxin A (OTA) from the point of view of its mechanism of action. OTA causes various toxic effects, such as nephrotoxicity, hepatotoxicity, immunosuppression, neurotoxicity and teratogenicity. However, the main issue concerning OTA effect is its carcinogenic potential in kidney, the target organ. The aim of this research project was to explore the impact of sex on OTA-induced gene expression response in order to determine the key events that might be involved in the early events of the carcinogenic process.